Our work in osteoarthritis has involved the careful measurement of bone, articular cartilage and menisci.

Imorphics models allow for very precise measurements of established tissue change such as the loss of articular cartilage. In addition, we have shown that the bone itself is a highly responsive tissue, usually ignored in clinical trials. Imorphics has pioneered the use of 3D bone shape as a sensitive and repeatable biomarker of OA, which promises to deliver osteoarthritis trials of the future with smaller patient cohorts and shorter time scales.